Adrenergic beta-antagonist: Difference between revisions
imported>Robert Badgett mNo edit summary |
imported>Robert Badgett No edit summary |
||
| Line 3: | Line 3: | ||
Beta-blockers vary within the class regarding intrinsic sympathomimetic activity (ISA), [[Adrenergic receptor|beta 1-selectivity]], membrane stabilizing activity, lipophilicity, and metabolism. This may lead to different effectiveness among this class of drugs. A [[meta-analysis]] has concluded that [[metoprolol]] may be the best beta-blocker for [[secondary prevention]] of [[myocardial infarction]].<ref name="pmid9122425">{{cite journal |author=Soriano JB, Hoes AW, Meems L, Grobbee DE |title=Increased survival with beta-blockers: importance of ancillary properties |journal=Prog Cardiovasc Dis |volume=39 |issue=5 |pages=445–56 |year=1997 |pmid=9122425 |doi= |url=http://linkinghub.elsevier.com/retrieve/pii/S0033-0620(97)80039-4 |issn=}}</ref> | Beta-blockers vary within the class regarding intrinsic sympathomimetic activity (ISA), [[Adrenergic receptor|beta 1-selectivity]], membrane stabilizing activity, lipophilicity, and metabolism. This may lead to different effectiveness among this class of drugs. A [[meta-analysis]] has concluded that [[metoprolol]] may be the best beta-blocker for [[secondary prevention]] of [[myocardial infarction]].<ref name="pmid9122425">{{cite journal |author=Soriano JB, Hoes AW, Meems L, Grobbee DE |title=Increased survival with beta-blockers: importance of ancillary properties |journal=Prog Cardiovasc Dis |volume=39 |issue=5 |pages=445–56 |year=1997 |pmid=9122425 |doi= |url=http://linkinghub.elsevier.com/retrieve/pii/S0033-0620(97)80039-4 |issn=}}</ref> | ||
==Availability== | |||
Generically available beta-blockers include:<ref name="pmid15912125">{{cite journal |author= |title=Drugs for hypertension |journal=Treat Guidel Med Lett |volume=3 |issue=34 |pages=39–48 |year=2005 |month=June |pmid=15912125 |doi= |url=http://www.medicalletter.org/scripts/articlefind.cgi?issue=34&page=39 |issn=}}</ref> | |||
* Atenolol (renally metabolized) | |||
* Betaxolol | |||
* Bisoprolol | |||
* Metoprolol (hepatically metabolized by [[cytochrome P-450]] | |||
* Nadolol | |||
* Propranolol | |||
* Timolol | |||
Generic beta-blockers with intrinsic sympathomimetic activity (less resting bradycardia and | |||
lipid changes):<ref name="pmid15912125"/> | |||
* Acebutolol | |||
* Pindolol | |||
Generic beta-blockers with alpha blocking activity (more orthostatic hypotension):<ref name="pmid15912125"/> | |||
* Labetalol | |||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 22:55, 19 May 2008
Adrenergic beta-receptor blockaders (beta-blockers) are "drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety".[1]
Beta-blockers vary within the class regarding intrinsic sympathomimetic activity (ISA), beta 1-selectivity, membrane stabilizing activity, lipophilicity, and metabolism. This may lead to different effectiveness among this class of drugs. A meta-analysis has concluded that metoprolol may be the best beta-blocker for secondary prevention of myocardial infarction.[2]
Availability
Generically available beta-blockers include:[3]
- Atenolol (renally metabolized)
- Betaxolol
- Bisoprolol
- Metoprolol (hepatically metabolized by cytochrome P-450
- Nadolol
- Propranolol
- Timolol
Generic beta-blockers with intrinsic sympathomimetic activity (less resting bradycardia and lipid changes):[3]
- Acebutolol
- Pindolol
Generic beta-blockers with alpha blocking activity (more orthostatic hypotension):[3]
- Labetalol
References
- ↑ Anonymous (2024), Adrenergic beta-antagonist (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Soriano JB, Hoes AW, Meems L, Grobbee DE (1997). "Increased survival with beta-blockers: importance of ancillary properties". Prog Cardiovasc Dis 39 (5): 445–56. PMID 9122425. [e]
- ↑ 3.0 3.1 3.2 (June 2005) "Drugs for hypertension". Treat Guidel Med Lett 3 (34): 39–48. PMID 15912125. [e]