Carboplatin: Difference between revisions

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Carboplatin may be dosed by the Calvert formula:<ref name="pmid2681557">{{cite journal| author=Calvert AH, Newell DR, Gumbrell LA, O'Reilly S, Burnell M, Boxall FE et al.| title=Carboplatin dosage: prospective evaluation of a simple formula based on renal function. | journal=J Clin Oncol | year= 1989 | volume= 7 | issue= 11 | pages= 1748-56 | pmid=2681557  
Carboplatin may be dosed by the Calvert formula:<ref name="pmid2681557">{{cite journal| author=Calvert AH, Newell DR, Gumbrell LA, O'Reilly S, Burnell M, Boxall FE et al.| title=Carboplatin dosage: prospective evaluation of a simple formula based on renal function. | journal=J Clin Oncol | year= 1989 | volume= 7 | issue= 11 | pages= 1748-56 | pmid=2681557  
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=2681557 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref>
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=2681557 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref>
:<math>{{Dose\ (mg) =\ target\ AUC \times (GFR + 25)}}</math>
:<math>Dose\ (mg)\ =\ target\ AUC \times\ (GFR + 25)</math>


==External links==
==External links==

Revision as of 16:39, 8 September 2009

In oncology, carboplatin is a antineoplastic agent that is an "organoplatinum compound that possesses antineoplastic activity."[1]

As compared to cisplatin, carboplatin has equal (lung cancer, ovarian cancer) or less (germ cell tumors, bladder cancer, head and neck cancer) efficacy but less drug toxicity.[2]

History

In the United States, it was approved with a New Drug Application (NDA) by the FDA in 1989.[3] A generic version was approved with a Abbreviated New Drug Application (ANDA) in 2003.[4]

Dosage

Carboplatin may be dosed by the Calvert formula:[5]

External links

The most up-to-date information about Carboplatin and other drugs can be found at the following sites.


References

  1. Anonymous (2024), Carboplatin (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. Lokich J, Anderson N (1998). "Carboplatin versus cisplatin in solid tumors: an analysis of the literature.". Ann Oncol 9 (1): 13-21. PMID 9541678.
  3. Drugs@FDA. U S Food and Drug Administration
  4. Drugs@FDA. U S Food and Drug Administration
  5. Calvert AH, Newell DR, Gumbrell LA, O'Reilly S, Burnell M, Boxall FE et al. (1989). "Carboplatin dosage: prospective evaluation of a simple formula based on renal function.". J Clin Oncol 7 (11): 1748-56. PMID 2681557.