Whipple's Disease: Difference between revisions

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imported>Robert Badgett
(New page: In medicine, '''Whipple's Disease''' is "a chronic systemic infection by a gram-positive bacterium, Tropheryma whippelii, mainly affecting the small instestine but also the [[joint...)
 
imported>Howard C. Berkowitz
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In [[medicine]], '''Whipple's Disease''' is "a chronic systemic infection by a gram-positive bacterium, Tropheryma whippelii, mainly affecting the [[small instestine]] but also the [[joint]]s; [[cardiovascular system]]; and the [[central nervous system]]. The disease is characterized by fat deposits in the [[intestinal mucosa]] and [[lymph node]]s, malabsorption, [[diarrhea]] with fatty stools, [[malnutrition]], and [[arthritis]]."<ref>{{MeSH}}</ref><ref name="pmid17202456">{{cite journal| author=Fenollar F, Puéchal X, Raoult D| title=Whipple's disease. | journal=N Engl J Med | year= 2007 | volume= 356 | issue= 1 | pages= 55-66 | pmid=17202456  
{{subpages}}
In [[medicine]], '''Whipple's Disease''', also called '''hepatolenticular degeneration''', is "a chronic systemic infection by a gram-positive bacterium, Tropheryma whippelii, mainly affecting the [[small instestine]] but also the [[joint]]s; [[cardiovascular system]]; and the [[central nervous system]]. The disease is characterized by fat deposits in the [[intestinal mucosa]] and [[lymph node]]s, malabsorption, [[diarrhea]] with fatty stools, [[malnutrition]], and [[arthritis]]."<ref>{{MeSH}}</ref><ref name="pmid17202456">{{cite journal| author=Fenollar F, Puéchal X, Raoult D| title=Whipple's disease. | journal=N Engl J Med | year= 2007 | volume= 356 | issue= 1 | pages= 55-66 | pmid=17202456  
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&retmode=ref&cmd=prlinks&id=17202456 | doi=10.1056/NEJMra062477 }} </ref>
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&retmode=ref&cmd=prlinks&id=17202456 | doi=10.1056/NEJMra062477 }} </ref>
==Diagnosis==
The disease involves abnormalities in metabolism of the trace element, [[copper]].


While not always present, one sign on physical examination is the [[Kayser-Fleischner ring]], a discoloration of the eye.
==References==
==References==
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Revision as of 07:58, 13 August 2010

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In medicine, Whipple's Disease, also called hepatolenticular degeneration, is "a chronic systemic infection by a gram-positive bacterium, Tropheryma whippelii, mainly affecting the small instestine but also the joints; cardiovascular system; and the central nervous system. The disease is characterized by fat deposits in the intestinal mucosa and lymph nodes, malabsorption, diarrhea with fatty stools, malnutrition, and arthritis."[1][2]

Diagnosis

The disease involves abnormalities in metabolism of the trace element, copper.

While not always present, one sign on physical examination is the Kayser-Fleischner ring, a discoloration of the eye.

References

  1. Anonymous (2024), Whipple's Disease (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. Fenollar F, Puéchal X, Raoult D (2007). "Whipple's disease.". N Engl J Med 356 (1): 55-66. DOI:10.1056/NEJMra062477. PMID 17202456. Research Blogging.