New Delhi metallo-beta-lactamase-1: Difference between revisions
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| journal = Indian J Med Microbiol [serial online] | date = 2010 [cited 2010 Sep 14] | volume = 28 | | journal = Indian J Med Microbiol [serial online] | date = 2010 [cited 2010 Sep 14] | volume = 28 | ||
| pages = 265-6. | | pages = 265-6. | ||
| url = http://www.ijmm.org/text.asp?2010/28/3/265/66477}}</ref> The gene to manufacture it can be [[horizontal gene transfer|horizontally transferred]] among different species of pathogenic bacteria. | | url = http://www.ijmm.org/text.asp?2010/28/3/265/66477}}</ref> The gene to manufacture it can be [[horizontal gene transfer|horizontally transferred]] among different species of pathogenic bacteria. | ||
First reported in ''[[Klebsiella pneumoniae]]'', it has been reported in ''[[Acinetobacter | Organisms that produce the enzyme are resistant to virtually all beta-lactam antibiotics except [[azneotram]]. <ref>>{{citation | ||
| author = Nordmann P, Poirel L. | |||
| title = Emerging carbapenemases in Gram-negative aerobes | |||
| journal = Clin Microbiol Infect | year = 2002 | volume = 8 | pages = 321-31 | |||
| url = http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1198-743X&date=2002&volume=8&issue=6&spage=321}}</ref> These organisms often are also resistant to [[fluoroquinolone]]s and [[aminoglycoside]]s. | |||
First reported in ''[[Klebsiella pneumoniae]]'', it has been reported in ''[[Acinetobacter baumanii]], [[Escherichia coli]], [[Citrobacter freundii]], [[Enterobacter cloacae]]'', and ''[[Morganella morganii]]''. A number of cases have been found in Britain, Canada and the US in patients that went to India for medical procedures or were treated for emergencies while in India.<ref>{{citation | |||
| title = NDM-1 carrying Enterobacteriaceae - worldwide ex India, Pakistan (02) | | title = NDM-1 carrying Enterobacteriaceae - worldwide ex India, Pakistan (02) | ||
| journal = ProMED Emerging Disease Report, International Society for Infectious Diseases | | journal = ProMED Emerging Disease Report, International Society for Infectious Diseases | ||
Revision as of 17:17, 14 September 2010
New Delhi metallo-beta-lactamase-1 enzyme confers bacterial resistance to antibiotics of the carbepenem class, often considered "last resort" drugs for multidrug resistant bacteria.[1] The gene to manufacture it can be horizontally transferred among different species of pathogenic bacteria.
Organisms that produce the enzyme are resistant to virtually all beta-lactam antibiotics except azneotram. [2] These organisms often are also resistant to fluoroquinolones and aminoglycosides.
First reported in Klebsiella pneumoniae, it has been reported in Acinetobacter baumanii, Escherichia coli, Citrobacter freundii, Enterobacter cloacae, and Morganella morganii. A number of cases have been found in Britain, Canada and the US in patients that went to India for medical procedures or were treated for emergencies while in India.[3]
References
- ↑ Krishna B (2010 [cited 2010 Sep 14]), "New Delhi metallo-beta-lactamases: A wake-up call for microbiologists", Indian J Med Microbiol [serial online] 28: 265-6.
- ↑ >Nordmann P, Poirel L. (2002), "Emerging carbapenemases in Gram-negative aerobes", Clin Microbiol Infect 8: 321-31
- ↑ "NDM-1 carrying Enterobacteriaceae - worldwide ex India, Pakistan (02)", ProMED Emerging Disease Report, International Society for Infectious Diseases, 14 September 2010